Stress-response and recovery models
Reed MC, Nijhout HF, Neuhouser ML, Gregory JF, Shane B, James SJ, Boynton A, Ulrich CM: A Mathematical Model Gives Insights into Nutritional and Genetic Aspects of Folate-Mediated One-Carbon Metabolism
These modifications are discussed in research literature for their effect on reducing binding affinity to insulin-like growth factor binding proteins, resulting in extended biological half-life in experimental models
Since poor absorption can be a problem with vitamin B12 which is the largest and most structurally complicated of the B vitamins patients need a formula that that can circumvent the stomach so that the B12 can efficiently reach the blood stream
Evidence for specific clinical outcomes is still evolving, and individual results vary